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Qué (quién) es tyrosinase$86060$ - definición
![burgundy]] to represent conservation grades from variable through conserved, respectively. At right is shown an alternative color scheme inspired by the earlier (now obsolete) ProteinExplorer's MSA3D (in which grades 4, 5, and 6 use the same color).](https://commons.wikimedia.org/wiki/Special:FilePath/Consurf tyrosinase protein.png?width=200 "burgundy]] to represent conservation grades from variable through conserved, respectively. At right is shown an alternative color scheme inspired by the earlier (now obsolete) ProteinExplorer's MSA3D (in which grades 4, 5, and 6 use the same color).")
![TRP-2]]- Tyrosinase- related protein 2](https://commons.wikimedia.org/wiki/Special:FilePath/Mason raper pathway.png?width=200 "TRP-2]]- Tyrosinase- related protein 2")
![type 3 copper center]]. From models C and D, the active site for this protein can be seen to sit within a pillus formed on the molecular surface of the molecule.](https://commons.wikimedia.org/wiki/Special:FilePath/PPO figure.jpeg?width=200 "type 3 copper center]]. From models C and D, the active site for this protein can be seen to sit within a pillus formed on the molecular surface of the molecule.")
![AAC17168]]), Snakes (Their genebank accession numbers [https://www.ncbi.nlm.nih.gov/protein/BBC55580 BBC55580], [https://www.ncbi.nlm.nih.gov/protein/XP_032076040 XP032076040] and [https://www.ncbi.nlm.nih.gov/protein/BBC55647 BBC55647]) and Human (Genebank accession number [https://www.ncbi.nlm.nih.gov/protein/AAA61242 AAA61242]) using Clustal Omega. (Note: (*) shows a conserved region,(.) shows more conserved and (:) shows less conserved.)](https://commons.wikimedia.org/wiki/Special:FilePath/Protein nucleotides.png?width=200 "AAC17168]]), Snakes (Their genebank accession numbers [https://www.ncbi.nlm.nih.gov/protein/BBC55580 BBC55580], [https://www.ncbi.nlm.nih.gov/protein/XP_032076040 XP032076040] and [https://www.ncbi.nlm.nih.gov/protein/BBC55647 BBC55647]) and Human (Genebank accession number [https://www.ncbi.nlm.nih.gov/protein/AAA61242 AAA61242]) using Clustal Omega. (Note: (*) shows a conserved region,(.) shows more conserved and (:) shows less conserved.)")
![nigromaculatus]] Wild, nA<sup>H</sup>: nigromaculatus Albino collected from Hiroshima. Numbers outside of the parenthesis refer to the amino acid position of the mutated species, and the number in the parenthesis refers to the associated amino acid position in the human sequence. (Miura et al. 2018)<ref name=":1" />](https://commons.wikimedia.org/wiki/Special:FilePath/Substituted amino acids of tyrosinase in albino frogs.png?width=200 "nigromaculatus]] Wild, nA<sup>H</sup>: nigromaculatus Albino collected from Hiroshima. Numbers outside of the parenthesis refer to the amino acid position of the mutated species, and the number in the parenthesis refers to the associated amino acid position in the human sequence. (Miura et al. 2018)<ref name=\":1\" />")
![CLUSTAL W]] program( version 1.7)and the phylogenetic trees were constructed by the Neighbour-joining method without distance correction. So ''Ambystoma and Xenopus'' do not cluster with other amphibians. Branches and nodes are drawn according to identical patterns.](https://commons.wikimedia.org/wiki/Special:FilePath/Tyrosinase phylogeny.png?width=200 "CLUSTAL W]] program( version 1.7)and the phylogenetic trees were constructed by the Neighbour-joining method without distance correction. So ''Ambystoma and Xenopus'' do not cluster with other amphibians. Branches and nodes are drawn according to identical patterns.")
Wikipedia
Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis otherwise known as the Raper Mason pathway. Firstly, the hydroxylation of a monophenol and secondly, the conversion of an o-diphenol to the corresponding o-quinone. o-Quinone undergoes several reactions to eventually form melanin. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. It is found inside melanosomes which are synthesized in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene.
